摘要：水滑石(LDH)负载Lewis酸催化剂作为一种绿色高效环境友好的新型负载催化剂，可极大提升Knoevenagel缩合反应的反应速率、缩短反应时间并减少后处理步骤。水滑石是一类具有天然层状结构的阴离子型主客体层状结构化合物, 具有酸碱性、层板上离子可交换性等特点，是Lewis酸的良好载体，可负载不同的Lewis酸制备负载催化剂催化Knoevenagel缩合反应。实验结果表明，以水滑石负载氯化铝(LDH/AlCl3）为催化剂，无水乙醇为溶剂，苯甲醛与巴比妥酸的物质的量之比为1:1时，在75℃条件下反应30min合成5-亚苄基巴比妥酸的产率可达98.3%。LDH负载Lewis酸催化剂可高效催化Knoevenagel缩合反应合成一系列巴比妥酸衍生物，反应条件温和，操作简便，产率较高，具有一定的工业化应用前景。
Abstract:As a novel green, efficient and environmentally friendly loaded catalyst, the hydrotalcite(LDH)-loaded Lewis acid catalyst greatly improves reaction rate, shortens reaction time and reduces work-up steps of Knoevenagel condensation reaction. LDH is a class of anionic host-guest lamellar compounds with natural lamellar structure, which has the characteristics of acid-base and ion-exchangeability on the lamellae, and it can be loaded with different Lewis acids to prepare loaded catalysts to catalyze the Knoevenagel condensation reaction. The experimental results showed that with LDH/AlCl3 as catalyst, anhydrous ethanol as solvent, and benzaldehyde and barbituric acid in the ratio of 1:1, the synthesis of 5-benzylidenebarbituric acid was achieved in a yield of up to 98.3% within 30 min at 75 ℃.The catalysts for the LDH-loaded Lewis acid catalyzed the condensation reaction of Knoevenagel in a highly efficient way. A series of barbituric acid derivatives were synthesized using the developed method. The protocol feature mild reaction conditions, simple operation, high yield, environmental friendliness, as well as prospects for industrialization.
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