【摘 要】
目的: 制备刺梨油微乳凝胶面膜，对其进行质量初步评价。方法：利用伪三元相图确定刺梨油微乳的最佳处方，结合单因素实验优化刺梨油微乳凝胶处方，并对制得的刺梨油微乳凝胶面膜进行评价。结果：刺梨油微乳最佳处方为：刺梨油0.1%，PEG-20氢化蓖麻油为0.68%，正丁醇为0.22%。刺梨油微乳凝胶最佳处方中卡波姆-940含量为 0.7 %。制得的刺梨油微乳凝胶面膜外观半透明，黏度适中，涂展性好，易清洗；测得刺梨油微乳凝胶pH值为6.0，黏度为457800.00 mPa·s，粒径为（46.66±0.02）nm，Zeta 电位为（-12.06±1.97) mV。结论：刺梨油微乳凝胶面膜制备工艺简单，具备推广与开发的价值。Abstract
Objective: This study aimed
to prepare a Rosa roxburghii oil microemulsion gel mask and conduct a
preliminary evaluation of its quality. Methods: The
optimal formulation for the Rosa roxburghii oil microemulsion was
determined using a pseudo-ternary phase diagram. Subsequently, the gel
formulation of the Rosa roxburghii oil microemulsion was optimized
through single-factor experiments, and the pharmaceutical properties of the
prepared gel mask were assessed. Results: The
optimal formulation for the Rosa roxburghii oil microemulsion consisted
of 0.10% Rosa roxburghii oil, 0.22% n-butanol, and 0.68% PEG-20. The
ideal formulation for the Rosa roxburghii oil microemulsion gel included
a carbomer-940 content of 0.7%. The resulting gel mask exhibited a translucent
appearance, moderate viscosity, good spreadability, and ease of cleaning. The
pH value of the gel was measured at 6.0, with a viscosity of 457,800.00 mPa·s, a
particle size of (46.66±0.02) nm, and a
Zeta potential of (-12.06±1.97) mV. Conclusion: The preparation process for the Rosa roxburghii
oil microemulsion gel mask is simple and stable, indicating its potential for
widespread application and development.
Abstract
Objective: This study aimed
to prepare a Rosa roxburghii oil microemulsion gel mask and conduct a
preliminary evaluation of its quality. Methods: The
optimal formulation for the Rosa roxburghii oil microemulsion was
determined using a pseudo-ternary phase diagram. Subsequently, the gel
formulation of the Rosa roxburghii oil microemulsion was optimized
through single-factor experiments, and the pharmaceutical properties of the
prepared gel mask were assessed. Results: The
optimal formulation for the Rosa roxburghii oil microemulsion consisted
of 0.10% Rosa roxburghii oil, 0.22% n-butanol, and 0.68% PEG-20. The
ideal formulation for the Rosa roxburghii oil microemulsion gel included
a carbomer-940 content of 0.7%. The resulting gel mask exhibited a translucent
appearance, moderate viscosity, good spreadability, and ease of cleaning. The
pH value of the gel was measured at 6.0, with a viscosity of 457,800.00 mPa·s, a
particle size of (46.66±0.02) nm, and a
Zeta potential of (-12.06±1.97) mV. Conclusion: The preparation process for the Rosa roxburghii
oil microemulsion gel mask is simple and stable, indicating its potential for
widespread application and development.
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