目的：对制备双苯乙烯类衍生物为荧光团的双光子荧光探针的中间产物2,5-二溴甲基对苯二甲腈及其衍生物的合成条件进行研究。方法：以对二甲苯为原料，通过芳环上的溴代、亲核取代和自由基反应等过程合成2,5-二溴甲基对苯二甲腈及其衍生物，然后通过柱层析方法进行纯化并用1HNMR确认其结构。结果:对合成工艺进行适当调整得到较好的效果。在2,5-二氰基对二甲苯的合成过程中，CuCN与2,5-二溴对二甲苯的摩尔配比换成2.1:1、反应时间调整为48小时时其产率提高。在2,5-二溴甲基对苯二甲腈的合成过程中未采用火焰枪辅助加热方法，而采用较温和的紫外灯照射方法。结论：通过反应物配比、加热温度和加热方法等的适当调节，摸索到简单易行的2,5-二溴甲基对苯二甲腈及其衍生物的合成方法。
Objective: This study interested in search of synthesis condition for 2,5-bisbromomethyl-1,4-dicyanobenzene and its derivatives, which are the intermediators of preparing a series of two-photon fluorescent probe with containing distyryl benzene derivatives as the two-photon fluorophores. Methods: p-Xylene as the starting material to synthesize 2,5-bisbromomethyl-1,4-dicyanobenzene and its derivatives by a series of reaction such as bromination on benzene ring, nucleophilic substitution and radical reactions, respectively. Then purified by silica gel column and the structures were confirmed by 1H NMR. Results: Through properly adjust on synthetic process, the research achieved good results. When the reactants molar ratio of CuCN and 2,5-dicyano-p-xylene was changed with 2.1:1, and the mixtures were reacted for 48 h, the yield of 2,5-dicyano-p-xylene was increased. When the process on synthesis of 2,5-bisbromomethyl-1,4-dicyanobenzene, the researchers used a wild condition such as ultraviolet irradiation, however another paper treated with flame gun auxiliary heating method. Conclusion: The research succeed in finding simple and easy way to synthesize 2,5-bisbromomethyl-1,4-dicyanobenzene and its derivatives by adjusting the reactants molar ratio, heating temperature, and heating time, etc.
订阅方式：
①在线订阅（推荐）：www.sdchem.net.cn
②邮局订阅：邮发代号24-109
投稿方式：
①在线投稿（推荐）：www.sdchem.net.cn
作者只需要简单注册获得用户名和密码后，就可随时进行投稿、查稿，全程跟踪稿件的发表过程，使您的论文发表更加方便、快捷、透明、高效。
②邮箱投稿：sdhgtg@163.com sdhg@sdchem.net
若“在线投稿”不成功，可使用邮箱投稿，投稿邮件主题：第一作者名字/稿件题目。
投稿时请注意以下事项：
①文前应有中英文“题目”、“作者姓名”、“单位”、“邮编”、“摘要”、“关键词”；
②作者简介包括：姓名、出生年、性别、民族、籍贯或出生地、工作单位、职务或职称、学位、研究方向；
③论文末应附“参考文献”，执行国标GB/T7714-2005标准，“参考文献”序号应与论文中出现的顺序相符；
④注明作者的联系方式，包括电话、E-mail、详细的通讯地址、邮编，以便联系并邮寄杂志。
欢迎投稿 答复快捷 发表迅速